Nax

https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13917

https://www.ncbi.nlm.nih.gov/pubmed/30903711?dopt=Abstract

Imiquimod-induced skin inflammation is relieved by knockdown of sodium channel Nax.

Exp Dermatol. 2019 Mar 23;:

Authors: Zhao J, Xie P, Galiano RD, Qi S, Mao R, Mustoe TA, Hong SJ

Abstract

Nax is an atypical sodium channel that mediates inflammatory pathways in pathological conditions of the skin. In this study, we developed a skin inflammation model in the rabbit ear through application of imiquimod (IMQ). Knockdown of Nax using RNAi attenuated IMQ-induced skin inflammation, including skin erythema, scaling, and papule formation. Histologic analysis showed that thickening and insufficient differentiation of the epidermis found in psoriasis-like skin were normalized by administration of Nax -RNAi. Excessive infiltration of inflammatory cells found in inflammatory lesions, such as mast cells, eosinophils, neutrophils, T cells, and macrophages, was reduced by Nax -RNAi. Expression of S100A9, which is a downstream gene of Nax and a mediator of inflammation, was decreased by Nax -RNAi. Our results demonstrated that knockdown of Nax ameliorated IMQ-induced psoriasis-like skin inflammation in vivo. Thus, targeting of Nax may represent a potential therapeutic option for the treatment of psoriasis. This article is protected by copyright. All rights reserved.

PMID: 30903711 [PubMed – as supplied by publisher]

Imiquimod-induced skin inflammation is relieved by knockdown of sodium channel Nax.

PubMed:30903711

Last Update Posted: 03/25/19 01:15PM